Abstract Artemisinin, qinghaosu, was extracted from the traditional Chinese medical drug qinghao the blue-green herb in the early s. The chemical structure of the active substance in this extract was identified in the late s and was found, totally unexpectedly, to be an sesquiterpene lactone peroxide. Pharmaceutical production of marketable drugs began in The World Health Organization WHO started to investigate artemisinin and its derivatives in the early s and has promoted them on a large scale since This is said without belittling the ingenuity and dedication to research of individuals such as Professor Tu Youyou at the China Academy of Traditional Chinese Medicine in Beijing and Professor Li Guoqiao at the Guangzhou University of Traditional Chinese Medicine, who have been credited nationally and internationally for their achievements, and other scientists who have worked just as hard but remain unnamed. Because malaria was a prime problem for all armed forces, military research institutions on both sides of the Pacific started to screen substances for their antimalarial properties. The idea of approaching an institution of traditional Chinese medicine reflected the nationalist fervour of Maoist China. Qinghao was among the first 10 items to be screened at the time, but no antimalarial properties were found, because the most active antimalarial substance in the plant extract, artemisinin, is soluble in neither water nor ether. Only 2—3 years later, after various abortive attempts in the laboratory, some brief spells in the field and a variety of projects with several collaborators, did Professor Tu Youyou and her research group develop an extraction method that proved successful.
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It also inferred that higher concentration is found in the regions with pH.5, but the average As is found to be higher in the pH > pH in groundwater may be increased by the previous sea water intrusion which further forms a favourable environment for ion exchange processes, and the increase in pH conditions favours desorption of As from.
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This increase is possible because the wavelengths of the electron beams are so much shorter than the wavelengths of light. Objects as small as 0. Specimens are observed by either transmission electron microscopy or scanning electron microscopy. In TEM the electron beam passes through the specimen and registers on a screen forming the image; in SEM the electron beam moves back and forth over the surface of microorganisms coated with a thin film of metal and registers a three-dimensional picture on the screen.
Scanning electron micrograph of the spirochete Treponema pallidum attached to testicular cell membranes. Among these are confocal microscopy, the atomic force microscope, the scanning tunneling microscope , and immunoelectron microscopy. These are particularly significant for studies of microorganisms at the molecular level. Nutritional and physiological characteristics Microorganisms as a group exhibit great diversity in their nutritional requirements and in the environmental conditions that will support their growth.
No other group of living organisms comes close to matching the versatility and diversity of microbes in this respect. Some species will grow in a solution composed only of inorganic salts one of the salts must be a compound of nitrogen and a source of carbon dioxide CO2 ; these are called autotrophs. Many, but not all, of these microbes are autotrophic via photosynthesis. Organisms requiring any other carbon source are called heterotrophs.
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Significantly overrepresented categories are shown by colors according to the panel and corresponding to odd ratios quantifying the enrichment of the particular GO term i. Phylogenetic connection of the Biscutelleae tribe to those of the extended lineage II remains to be clarified Couvreur et al. Future phylogenomic work will address the progenitor s of this mesopolyploid lineage, but we note that related genera present high chromosome numbers e.
The transcriptome of Buckler mustard assembled by combining advantages of short and long reads into a set of long and framed transcripts largely confirmed cytogenetic conclusions and offered additional insights on the evolutionary processes underlying WGD fractionation cycles. Consistent peaks in the distribution of Ks between duplicated transcripts highlighted four WGD events in the history of Buckler mustard.
This period was characterized by increasing seasonal aridity as well as major climatic changes such as the Messinian salinity crisis that strongly impacted Mediterranean vegetation Blondel et al. It thus seems likely that environmental changes favored the Bl-m-WGD event among Biscutella ancestors. The n-WGD event thus also points to a period with major environmental changes across the Buckler mustard distribution range. Although Ks-based estimates offer rough dates to be taken with caution, recurrent WGD events in Buckler mustard appear consistent with data available from other species Kagale et al.
Recurrent WGDs followed by chromosome repatterning and descending dysploidy leading to diploid-like chromosome numbers within a few million years, as observed here, are fully congruent with genome dynamics reported in other Brassicaceae clades Bowers et al. Compared with other species having undergone a WGD event at the same time and still showing polyploid chromosome numbers Kagale et al.
Similarly remarkable post- WGD genome evolution was also reported in the genus Brassica Chalhoub et al.
ShareCompartir BV is a polymicrobial clinical syndrome resulting from replacement of the normal hydrogen peroxide producing Lactobacillus sp. Some women experience transient vaginal microbial changes, whereas others experience them for longer intervals of time. Among women presenting for care, BV is the most prevalent cause of vaginal discharge or malodor; however, in a nationally representative survey, most women with BV were asymptomatic BV is associated with having multiple male or female partners, a new sex partner, douching, lack of condom use, and lack of vaginal lactobacilli; women who have never been sexually active are rarely affected The cause of the microbial alteration that precipitates BV is not fully understood, and whether BV results from acquisition of a single sexually transmitted pathogen is not known.
BV also increases the risk for HIV transmission to male sex partners
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Maternal Hypothalamus and Pituitary Little information is definitively known about the endocrine alterations of the maternal hypothalamus during pregnancy. Thought to result from estrogen stimulation, the anterior pituitary undergoes a 2- to 3-fold enlargement during pregnancy, primarily because of hyperplasia and hypertrophy of lactotroph cells. Thus, plasma prolactin levels parallel the increase in pituitary size throughout gestation.
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The formal and legal documentation of an incoming repository transaction, including a gift, purchase, exchange, transfer, or field collection. File that contains the documentation for each incoming repository transaction, including all legal records. Often includes the documentation of a deaccession. A unique number assigned to a collection or, in some cases, an object for purposes of identification not description Buck and Gilmore ; Griset and Kodack A colorless, highly flammable liquid that is soluble in water.
Commonly used as a solvent for adhesives. A process to obtain custody of an object, document, or collection that involves physical transfer. Acrylic resin used as a consolidant, as a barrier material or base coat to label objects, and as an adhesive. Interventive treatment action taken to increase the stability or durability of an object.
The process of determining the monetary value of an item.
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Thereafter, the bacterial cells were harvested at g for 10 min and washed with ml of M 1× PBS (pH ), followed by resuspension in 2 ml of Middlebrook 7H9 medium supplemented with % Tween and OADC (Becton Dickinson). To disperse clumps, cells were vortexed briefly in the presence of 2-mm glass beads.
Advanced Search Abstract In singleton pregnancies after IVF a high rate of preterm deliveries and an increased rate of small-for-gestational age SGA children in comparison to the general parturient population have been reported. However, due to differences between IVF mothers and their peers who conceived naturally, careful selection of the control group is necessary to assess whether IVF pregnancies really carry increased risks of adverse outcome.
In our study IVF pregnancies were compared with control pregnancies after elaborate matching for an extensive number of maternal characteristics, as well as for the hospital that provided the obstetric care. Four Dutch university hospitals contributed to the study. The combination of these two results denotes a distinct difference between IVF and control pregnancies. Placental weight was comparable in both groups.
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Twelve black and six red fountain inks have been collected, and their ink entries have been prepared by drawing lines on paper. The chromatographic conditions for separation of their dye components after extraction with solvents were optimized. Under the optimized conditions, the 18 fountain pen inks were differentiated individually by comparing the number of detectable main or minor dye components, and the relative peak intensities of each component.
The ink entries were artificially and naturally aged, and the analysis results showed that the ink dye components were significantly decomposed when exposed to UV or fluorescent light compare to those of inks stored under natural condition.
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Why are there no microbial requirements included in the monographs for Purified Water and Water for Injection? Alert and Action Levels are process control terms and should be established at levels indicative of the water system trending outside of its normal microbial control range. The purpose of Alert and Action Levels is to trigger additional, non-routine, rather than routine microbial control measures.
For off-line testing of water samples for Water Conductivity and Total Organic Carbon , how long can I store samples before testing? USP is silent on a specific answer to this question. It is understood that some manufacturers have their analyses performed by external laboratories — which may take several days or longer. For this reason, there is no time limit. In general, you can wait as long as you want — at your risk. But it is advised to test as soon as practical for the following reasons; 1 when stored, the water purity only degrades over time.
Since Purified Water, Water for Injection or the sterile waters are of such high purity, the passage of time does not do anything except potentially degrade the sample due to environmental, ambient, or container factors; and 2 water is typically not produced in batches, but rather it is usually purified, produced, and consumed continuously.